913239-29-9

Basic information

• Product Name: diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate
• Synonyms: diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate
• CAS NO: 913239-29-9
• Molecular Weight: 610.647
• Mol File: 913239-29-9.mol

Chemical Properties

• CAS DataBase Reference: diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate(913239-29-9)
• EPA Substance Registry System: diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate(913239-29-9)

Safety Data

• Hazardous Substances Data: 913239-29-9(Hazardous Substances Data)

Upstream product

• 695172-02-2 diphenyl 1-benzyloxycarbonylamino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)phenyl)ethanephosphonate 
• 623-04-1 4-aminobenzenemethanol 
• 144072-30-0 4-((tert-butoxycarbonyl)amino)benzaldehyde 
• 144072-29-7 tert-butyl N-[4-(hydroxymethyl)phenyl]carbamate 
• 152120-54-2 (Z)-tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate 
• 934622-37-4 benzyl 2-(4-aminophenyl)-1-(diphenoxyphosphoryl)ethylcarbamate 
• 695171-95-0 diphenyl 1-benzyloxycarbonylamino-2-(4-(tert-butyloxycarbonylamino)phenyl)ethanephosphonate 
• 695172-02-2 diphenyl 1-(benzyloxycarbonylamino)-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 695171-91-6 4-(tert-butyloxycarbonylamino)phenylacetaldehyde 
• 104060-23-3 tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate 

Downstream Products

• 695172-09-9 diphenyl 1-((N-benzyloxycarbonyl-L-alanyl)amino)-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)phenyl)ethanephosphonate 
• 934622-15-8 diphenyl 1-(o-toluenesulfonylamino)-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidine]phenyl}ethanephosphonate 
• 934622-63-6 diphenyl 1-acetamido-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethyl-phosphonate 
• 934622-13-6 diphenyl 1-(benzoylamino)-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidine]phenyl}ethanephosphonate 

Relevant articles and documents

Phosphonate inhibitors of West Nile virus NS2B/NS3 protease

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In this letter we report the synthesis and biochemical evaluation of selective, irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator (uPA). A diphenyl phosphonate group was introduced on the substratelike peptide Z-D-Ser-Ala-Arg, and modification of the guanidine side chain was investigated. A guanylated benzyl group appeared the most promising side chain modification. A kapp value in the 103 M -1 s-1 range for uPA was obtained, together with a selectivity index higher than 240 toward other trypsin-like proteases such as tPA, thrombin, plasmin, and FXa.