methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate

Base Information

• Chemical Name: methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate
• CAS No.: 350583-44-7
• Molecular Formula: C₁₆H₂₇NO₃Si
• Molecular Weight: 309.481
• Mol file: 350583-44-7.mol

Synonyms:methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate

Chemical Property of methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate

There total 3 articles about methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester (350583-35-6) → methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate (350583-44-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 20h;

DOI:10.1002/1099-0690(200105)2001:9<1761::AID-EJOC1761>3.0.CO;2-O

Reference yield:

triethylsilyl chloride (994-30-9) → methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate (350583-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylamine / tetrahydrofuran

2: 2.58 g / H₂ / Pd/C / ethyl acetate / 20 h

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1002/1099-0690(200105)2001:9<1761::AID-EJOC1761>3.0.CO;2-O

Reference yield:

Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate (99458-15-8) → methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate (350583-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylamine / tetrahydrofuran

2: 2.58 g / H₂ / Pd/C / ethyl acetate / 20 h

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1002/1099-0690(200105)2001:9<1761::AID-EJOC1761>3.0.CO;2-O

upstream raw materials:

(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

triethylsilyl chloride

Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate

Downstream raw materials:

(3R,4S)-3-triethylsilyloxy-4-phenylazetidin-2-one

(3R,4S)-1-benzoyl-4-phenyl-3-(triethylsilyl)oxy-2-azetidinone

C₅₆H₇₃NO₁₄Si