(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

Base Information

Chemical Name:(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester
CAS No.:350583-35-6
Molecular Formula:C₁₆H₂₅N₃O₃Si
Molecular Weight:335.478
Hs Code.:

Synonyms:(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

There total 1 articles about (2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 994-30-9
triethylsilyl chloride

: 99458-15-8
Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate

: 350583-35-6
(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran;
DOI:10.1002/1099-0690(200105)2001:9<1761::AID-EJOC1761>3.0.CO;2-O

Reference yield:

: 350583-35-6
(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

: 149249-91-2
(3R,4S)-1-benzoyl-4-phenyl-3-(triethylsilyl)oxy-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2.58 g / H₂ / Pd/C / ethyl acetate / 20 h

2.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C

2.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C

3.1: 87 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 20 °C

With dmap; chloro-trimethyl-silane; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1002/1099-0690(200105)2001:9<1761::AID-EJOC1761>3.0.CO;2-O

Reference yield:

: 350583-35-6
(2R,3S)-3-Azido-3-phenyl-2-triethylsilanyloxy-propionic acid methyl ester

: 350583-44-7
methyl (2R,3S)-3-amino-3-phenyl-2-(triethylsilyloxy)propanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 20h;
DOI:10.1002/1099-0690(200105)2001:9<1761::AID-EJOC1761>3.0.CO;2-O