tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate

Base Information

• Chemical Name: tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate
• CAS No.: 1072004-22-8
• Molecular Formula: C₂₀H₂₂N₂O₆
• Molecular Weight: 386.404

Synonyms:tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate

Chemical Property of tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate

Chemical Property:

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Technology Process of tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate

There total 2 articles about tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-dihydro-6-hydroxybenzofuran (23681-89-2) + N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester (299176-17-3) → tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate (1072004-22-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.09.006

Reference yield:

→ tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate (1072004-22-8)

Guidance literature:

Reference yield:

tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate (1072004-22-8) → tert-Butyl [2-amino-5-(2,3-dihydro-1-benzofuran-6-yloxy)phenyl]methylcarbamate (1072004-23-9)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 5h; Reflux;

DOI:10.1016/j.bmc.2018.09.006

upstream raw materials:

2,3-dihydro-6-hydroxybenzofuran

N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

Downstream raw materials:

methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid

methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-(2,3-dihydro-1-benzofuran-6-yloxy)phenyl}amino)-2-oxoethoxy]benzoate

tert-Butyl [2-amino-5-(2,3-dihydro-1-benzofuran-6-yloxy)phenyl]methylcarbamate

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