methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

Base Information

Chemical Name:methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride
CAS No.:1072004-25-1
Molecular Formula:C₂₅H₂₂N₂O₅*ClH
Molecular Weight:466.921
Hs Code.:

Synonyms:methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

Suppliers and Price of methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

There total 7 articles about methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1072004-24-0
methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-(2,3-dihydro-1-benzofuran-6-yloxy)phenyl}amino)-2-oxoethoxy]benzoate

: 1072004-25-1
methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 2h; Reflux;

Reference yield:

: 1072004-22-8
tert-butyl [5-(2,3-dihydro-1-benzofuran-6-yloxy)-2-nitrophenyl]methylcarbamate

: 1072004-25-1
methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / ethanol; water / 5 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate / 4 h / 60 °C

With hydrogenchloride; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmc.2018.09.006

Reference yield:

: 23681-89-2
2,3-dihydro-6-hydroxybenzofuran

: 1072004-25-1
methyl 3-{[6-(2,3-dihydro-1-benzofuran-6-yloxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / 5 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C / Inert atmosphere

4: hydrogenchloride / ethyl acetate / 4 h / 60 °C

With hydrogenchloride; iron; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.09.006