1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate
CAS No.:720692-43-3
Molecular Formula:C₂₂H₂₇NO₃
Molecular Weight:353.461
Hs Code.:

Synonyms:1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

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Chemical Property of 1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

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Technology Process of 1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

There total 1 articles about 1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 100-39-0
benzyl bromide

: 149354-10-9
3-(tert-butyloxycarbonyl)-7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine

: 720692-43-3
1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Guidance literature:: With potassium carbonate; potassium iodide; In butanone; for 24h; Heating / reflux;

Reference yield: 93.0%

: 720692-43-3
1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 720692-44-4
7-[(phenylmethyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: 1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With ammonia; In methanol; water;

Reference yield:

: 720692-43-3
1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 3-cyclobutyl-7-phenoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: SCX ion exchange column Varian BOND-ELUTE

2.1: acetic acid / dichloromethane / 0.5 h / 0 °C

2.2: 4 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 5 h / 20 °C / 760.05 Torr

4.1: pyridine; sodium hydride; copper(I) bromide / 0.5 h / 0 - 20 °C

4.2: 24 h / Heating / reflux

With pyridine; hydrogen; sodium hydride; acetic acid; trifluoroacetic acid; copper(I) bromide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;