1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone

Base Information

Chemical Name:1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone
CAS No.:871737-40-5
Molecular Formula:C₂₄H₂₈N₂O₂
Molecular Weight:376.499
Hs Code.:

Synonyms:1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone

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Chemical Property of 1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone

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Technology Process of 1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone

There total 6 articles about 1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 616-45-5
2-pyrrolidinon

: 871737-48-3
3-cyclobutyl-7-[(4-iodophenyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine

: 871737-40-5
1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 140 ℃; for 1h;

Reference yield:

: 720692-44-4
7-[(phenylmethyl)oxy]-2,3,4,5-tetrahydro-1H-3-benzazepine

: 871737-40-5
1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 0.5 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 5 h / 20 °C / 760.05 Torr

3.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 0.33 h / 200 °C

4.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 1 h / 140 °C

With copper(l) iodide; hydrogen; potassium carbonate; caesium carbonate; acetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;

Reference yield:

: 720692-43-3
1,1-dimethylethyl 7-[(phenylmethyl)oxy]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 871737-40-5
1-{4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]phenyl}-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: SCX

2.1: acetic acid / dichloromethane / 0.5 h / 0 °C

2.2: 4 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 5 h / 20 °C / 760.05 Torr

4.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 0.33 h / 200 °C

5.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 1 h / 140 °C

With copper(l) iodide; hydrogen; potassium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;