ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

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Chemical Name:ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate
CAS No.:1421850-06-7
Molecular Formula:C₂₂H₂₅N₃O₃S
Molecular Weight:411.525
Hs Code.:

Synonyms:ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

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Chemical Property of ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

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Technology Process of ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

There total 8 articles about ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.3%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1421850-05-6
2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

: 1421850-06-7
ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.25h;

2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 5h;

Reference yield:

: 2881-83-6
ethyl 4-methoxybenzoylacetate

: 1421850-06-7
ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / 14 h / 90 °C

1.2: 20 h / 80 °C

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 20 °C

3.1: thionyl chloride / toluene / 2.5 h / 100 °C

3.2: 14 h / 20 °C

4.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

5.1: ethanol / 14 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

7.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

8.2: 5 h / 0 - 20 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; water; sulfur trioxide pyridine complex; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene; mineral oil;

Reference yield:

: 1421848-81-8
1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid

: 1421850-06-7
ethyl (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / toluene / 2.5 h / 100 °C

1.2: 14 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

3.1: ethanol / 14 h / 90 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

5.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

6.2: 5 h / 0 - 20 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; sulfur trioxide pyridine complex; sodium hydride; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene; mineral oil;