Ethyl 4-amino-2-hydroxybenzoate

Base Information

• Chemical Name: Ethyl 4-amino-2-hydroxybenzoate
• CAS No.: 6059-17-2
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Hs Code.: 2922509090
• UNII: CUR96KD6FU
• DSSTox Substance ID: DTXSID60209390
• Nikkaji Number: J81.138F
• Wikidata: Q83083670
• Mol file: 6059-17-2.mol

Synonyms:Ethyl 4-amino-2-hydroxybenzoate;6059-17-2;Pas ethyl ester;Ethyl p-aminosalicylate;p-Aminosalicylic acid ethyl ester;Pas aethyl ester;Pas aethyl ester [German];Benzoic acid, 4-amino-2-hydroxy-, ethyl ester;Ethyl 4-aminosalicylate;CUR96KD6FU;BRN 2092242;Salicylic acid, amino-, ethyl ester;Benzoic acid, 4-amino-2-hydroxy-, ethyl ester (9CI);Ethyl 4-Amino-2-hydroxybenzoate (Ethyl Aminosalicylate);4-Aminosalicylic acid, ethyl ester;UNII-CUR96KD6FU;Ethyl4-amino-2-hydroxybenzoate;SCHEMBL1480079;DTXSID60209390;ethyl 4-amino-2-hydroxy-benzoate;AKOS009115131;Salicylic acid, 4-amino-, ethyl ester;4-amino-2-hydroxybenzoic acid ethyl ester;LS-144239;P-AMINOSALICYLIC ACID ETHYL ESTER [MI];EN300-5006201

Chemical Property of Ethyl 4-amino-2-hydroxybenzoate

Chemical Property:

• Vapor Pressure: 4.76E-05mmHg at 25°C
• Melting Point: 113 °C
• Boiling Point: 339.2°C at 760 mmHg
• PKA: 9.98±0.10(Predicted)
• Flash Point: 158.9°C
• PSA: 72.55000
• Density: 1.253g/cm³
• LogP: 1.73230
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 181.07389321
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-hydroxy-benzoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C(C=C(C=C1)N)O

Technology Process of Ethyl 4-amino-2-hydroxybenzoate

There total 6 articles about Ethyl 4-amino-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

ethanol (64-17-5) + 4-Aminosalicylic acid (65-49-6) → ethyl 4-amino-2-hydroxybenzoate (6059-17-2)

Guidance literature:

With sulfuric acid; at 80 ℃; Cooling with ice;

Reference yield: 7.4%

→ ethyl 4-amino-2-hydroxybenzoate (6059-17-2)

Guidance literature:

Reference yield:

2-hydroxy-4-nitro-benzoic acid ethyl ester (78987-51-6) → ethyl 4-amino-2-hydroxybenzoate (6059-17-2)

Guidance literature:

With 2-methoxy-ethanol; platinum; Hydrogenation;

upstream raw materials:

2-hydroxy-4-nitro-benzoic acid ethyl ester

ethanol

4-Aminosalicylic acid

2-hydroxy-4-nitrobenzoic acid

Downstream raw materials:

2,2'-dihydroxy-4,4'-methanediyldiamino-di-benzoic acid diethyl ester

4-ethoxycarbonylamino-2-hydroxy-benzoic acid ethyl ester

ethyl 4-acetylamino-o-hydroxybenzoate

10-{[N'-(4-amino-2-hydroxy-benzoyl)-hydrazino]-acetyl}-10H-phenothiazine

Refernces

• 1、 -. "Fluoroquinolone derivative of p-aminosalicylic acid as well as intermediate, preparation method and application of fluoroquinolone derivative". Paragraph 0051; 0090-0092. . Retrieved 2021/01/24.
• 2、 -. "para-aminosalicylic acid azole derivative as well as preparation method and application thereof". Paragraph 0051; 0084-0086. . Retrieved 2020/12/15.