(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

Base Information

Chemical Name:(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester
CAS No.:1083429-84-8
Molecular Formula:C₂₇H₂₉F₃N₆O₄
Molecular Weight:558.56
Hs Code.:

Synonyms:(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

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Chemical Property of (2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

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Technology Process of (2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

There total 5 articles about (2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947249-01-6
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3-trifluoromethyl-pyridin-2-ylamine

: 1083429-91-7
{2-[4-(3-bromo-2-methyl-imidazo[1,2-b]pyridazin-6-yl)-2-methoxy-phenoxy]-ethyl}-carbamic acid tert-butyl ester

: 1083429-84-8
(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

Guidance literature:: With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In ISOPROPYLAMIDE; water; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 1083429-84-8
(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 8 h / 115 °C

2: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.5 h / 150 °C / Microwave irradiation

With potassium acetate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ISOPROPYLAMIDE; water;

Reference yield:

: 1083429-87-1
2-methoxy-4-(2-methyl-imidazo[1,2-b]pyridazin-6-yl)-phenol

: 1083429-84-8
(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / ISOPROPYLAMIDE / 8 h / 100 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 0 - 5 °C

3: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.5 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;