(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Base Information

Chemical Name:(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate
CAS No.:1426828-70-7
Molecular Formula:C₇₆H₉₁N₃O₈S₂Si
Molecular Weight:1266.79
Hs Code.:

(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Synonyms:(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Suppliers and Price of (3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

There total 10 articles about (3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1027785-35-8
(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

: 1426828-65-0
(3S,4R)-allyl 4-[(S)-2-amino-3-(tritylthio)propanamido]-3-(tert-butyldimethylsiloxy)-6-methylheptanoate

: 1426828-70-7
(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at -30 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.12.023

Reference yield:

: 116662-96-5
(2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal

: 1426828-70-7
(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.67 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: sodium hydroxide / ethanol / 6 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

5.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 1 h / 20 °C

5.2: 1 h / 0 - 20 °C

6.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 1 h / 20 °C

6.2: 1 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 3 h / -30 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; trimethylsilyl trifluoromethanesulfonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.12.023

Reference yield:

: 114155-31-6
ethyl (R)-4-(carboxyamino)-6-methyl-3-oxoheptanoate 4-tert-butyl ester

: 1426828-70-7
(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-6-methylheptanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium borohydride / methanol / 5 h / -40 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: sodium hydroxide / ethanol / 6 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

5.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 1 h / 20 °C

5.2: 1 h / 0 - 20 °C

6.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 1 h / 20 °C

6.2: 1 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 3 h / -30 °C / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; potassium borohydride; trimethylsilyl trifluoromethanesulfonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.12.023