4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester

Base Information

• Chemical Name: 4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester
• CAS No.: 162010-79-9
• Molecular Formula: C₈H₈N₂O₆S
• Molecular Weight: 260.227
• Mol file: 162010-79-9.mol

Synonyms:4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester

Chemical Property of 4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester

There total 4 articles about 4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorosulfonyl-3-nitrobenzoic acid methyl ester (162010-78-8) → 4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester (162010-79-9)

Guidance literature:

With ammonia; In acetonitrile; at 25 ℃; for 1h;

Reference yield:

methyl 3-nitro-4-chlorobenzoate (14719-83-6) → 4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester (162010-79-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium sulfide / N,N-dimethyl-formamide / 16 h / 20 °C

2: N-chloro-succinimide; hydrogenchloride / acetonitrile / 16 h / 20 °C

3: ammonia / acetonitrile / 1 h / 25 °C

With hydrogenchloride; sodium sulfide; N-chloro-succinimide; ammonia; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

4-mercapto-3-nitro-benzoic acid methyl ester (59515-34-3) → 4-(Aminosulfonyl)-3-nitrobenzenecarboxylic acid, methyl ester (162010-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide; hydrogenchloride / acetonitrile / 16 h / 20 °C

2: ammonia / acetonitrile / 1 h / 25 °C

With hydrogenchloride; N-chloro-succinimide; ammonia; In acetonitrile;

upstream raw materials:

methyl 3-nitro-4-chlorobenzoate

4-mercapto-3-nitro-benzoic acid methyl ester

4-chlorosulfonyl-3-nitrobenzoic acid methyl ester

Downstream raw materials:

3-Amino-4-sulfamoyl-benzoic acid methyl ester