4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

Base Information

Chemical Name:4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide
CAS No.:1374203-86-7
Molecular Formula:C₃₁H₃₄N₆O₄
Molecular Weight:554.649
Hs Code.:

Synonyms:4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

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Chemical Property of 4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

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Technology Process of 4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

There total 8 articles about 4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1374208-63-5
2-(2-chloro-4-morpholino-quinazolin-7-yl)propan-2-ol

: 1374208-23-7
N,N-dimethyl-4-{3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2yl)phenyl]-ureido}-benzamide

: 1374203-86-7
4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

Guidance literature:: With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 95 ℃; for 5.33333h; Inert atmosphere;

Reference yield:

: 7291-01-2
N,N-dimethyl-4-nitrobenzamide

: 1374203-86-7
4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / palladium 10% on activated carbon / 3.17 h / 3102.97 Torr / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12.17 h / 105 °C / Inert atmosphere

4: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5.33 h / 95 °C / Inert atmosphere

With methanol; potassium acetate; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1374203-86-7
4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; ethylene dichloride hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

2: methanol / palladium 10% on activated carbon / 3.17 h / 3102.97 Torr / Inert atmosphere

3: triethylamine / dichloromethane / 12 h / 20 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12.17 h / 105 °C / Inert atmosphere

5: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5.33 h / 95 °C / Inert atmosphere

With methanol; ethylene dichloride hydrochloride; potassium acetate; benzotriazol-1-ol; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;