7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester

Base Information

• Chemical Name: 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
• CAS No.: 174074-88-5
• Molecular Formula: C₁₀H₈N₂O₄
• Molecular Weight: 220.185
• Hs Code.: 2933990090
• Mol file: 174074-88-5.mol

Synonyms:2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester; methyl 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate; 7-methylcarboxylate-1H-quinazoline-2,4-dione; Methyl 2,4-dihydroxyquinazoline-7-carboxylate; methyl 2,4-dihydroxyquinazoline-7-carboxylate

Chemical Property of 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester

Chemical Property:

• Melting Point: 307-309 °C
• PKA: 9.82±0.20(Predicted)
• PSA: 92.54000
• Density: 1.382±0.06 g/cm3(Predicted)
• LogP: 0.82760
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

methyl2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester

There total 2 articles about 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dimethyl 2-[(aminocarbonyl)amino]terephthalate (956100-56-4) → methyl 2,4-dihydroxyquinazoline-7-carboxylate (174074-88-5)

Guidance literature:

dimethyl 2-[(aminocarbonyl)amino]terephthalate; With sodium methylate; In methanol; for 16h; Heating / reflux;

With hydrogenchloride; In methanol; water; at 0 ℃; pH=2;

Reference yield: 80.0%

acetamide (60-35-5) + dimethyl aminoterephthalate (5372-81-6) → 2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester (174074-88-5)

Guidance literature:

at 200 ℃; for 3h;

Reference yield: 59.0%

methyl 2,4-dihydroxyquinazoline-7-carboxylate (174074-88-5) → methyl 2,4-dichloroquinazoline-7-carboxylate (174074-89-6)

Guidance literature:

methyl 2,4-dihydroxyquinazoline-7-carboxylate; With phosphorus pentachloride; trichlorophosphate; Heating / reflux;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 1h;

upstream raw materials:

acetamide

dimethyl aminoterephthalate

dimethyl 2-[(aminocarbonyl)amino]terephthalate

Downstream raw materials:

methyl 2,4-dichloroquinazoline-7-carboxylate

4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide

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