7291-01-2

Usage

InChI:InChI=1/C9H10N2O3/c1-10(2)9(12)7-3-5-8(6-4-7)11(13)14/h3-6H,1-2H3

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 124-40-3 dimethyl amine 
• 3984-14-3 N,N-dimethylsulfamide 
• 62-23-7 4-nitro-benzoic acid 
• 3732-84-1 diphenylphosphinic acid dimethylamide 
• 106997-51-7 C₁₀H₁₃N₂O₆P 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 1624-01-7 tetrakis(dimethylamino)silane 
• 555-16-8 4-nitrobenzaldehdye 
• 4375-83-1 tris(dimethylamino)borane 
• 506-59-2 N,N-dimethylammonium chloride 
• 636-98-6 p-nitrobenzene iodide 
• 49771-93-9 o-dimethylamino methyl phenyl silver 

Downstream Products

• 6331-71-1 4-amino-N,N-dimethylbenzamide 
• 109821-06-9 4,4'-azoxy-di-benzoic acid bis-dimethylamide 
• 15184-96-0 4-(N,N-dimethylaminomethyl)nitrobenzene 
• 93282-12-3 N-(chloro(4-nitrophenyl)methylene)-N-methylmethanaminium chloride 
• 63833-38-5 2,4-dimethyl-5-(4-nitro-benzoyl)-pyrrole-3-carboxylic acid ethyl ester 
• 58863-41-5 4-nitro-dithiobenzoic acid methyl ester 
• 122129-65-1 (E)-2,3-Difluoro-1-(4-nitro-phenyl)-3-phenyl-propenone 
• 122129-71-9 (E)-3-(4-Dimethylamino-phenyl)-2,3-difluoro-1-(4-nitro-phenyl)-propenone 
• 96308-24-6 4-(2,2,2-trifluoroethoxy)-N,N-dimethylbenzamide 
• 555-16-8 4-nitrobenzaldehdye 
• 90238-18-9 [Difluoro-(4-nitro-phenyl)-methyl]-dimethyl-amine 
• 186752-48-7 4-chloro-2-(4-nitrophenyl)-5,6-dihydrobenzo[h]quinazoline 
• 496052-96-1 [5-(4-nitrobenzoyl)-1H-pyrrol-2-yl]acetic acid ethyl ester 
• 2585-23-1 N-methyl-4-nitrobenzamide 

Relevant academic research and scientific papers

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

One-pot synthesis of a highly disperse core-shell CuO-alginate nanocomposite and the investigation of its antibacterial and catalytic properties

In this study, sodium alginate was extracted from Sargassum algae, collected from coastal waters of Bushehr, Persian Gulf, Iran and used as a stabilizing and wrapping agent for CuO nanoparticles. The synthesized nanocomposite was characterized by some spectroscopic and microscopic techniques, such as IR, XRD, Uv-vis, BET, BJH, zeta potential, SEM, TEM, HR-TEM, and XPS. The antibacterial effects of the CuO-alginate nanocomposite against some bacteria, isolated from a burn wound, were evaluated. The results showed that this nanocomposite had better antibacterial effects than its components onPseudomonas aeruginosaATCC 27853,Staphylococcus aureusATCC 12600,Streptococcus pyogenesATCC 19615, andStaphylococcus epidermidisATCC 49461. Among these,Staphylococcus aureusATCC 12600 was the most sensitive one to this nanocomposite, with the lowest minimum inhibitory concentration (2.08 mg mL?1) observed. Moreover, the synthesized nanocomposite showed good catalytic activity in the oxidative coupling of carboxylic acids withN,N-dialkylformamides toward the synthesis of amides.

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Palladium-Catalyzed Aminocarbonylation of Aryl Halides with N,N-Dialkylformamide Acetals

We developed a protocol for the palladium-catalyzed aminocarbonylation of aryl halides using less-toxic formamide acetals as bench-stable aminocarbonyl sources under neutral conditions. Various aryl (including heteroaryl) halides reacted with N,N-dialkylformamide acetals in the presence of a catalytic amount of tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct and xantphos to give the corresponding aromatic carboxamides at 90–140 °C without any activating agents or bases in up to quantitative chemical yield. This protocol was applied to aryl bromides, aryl iodides, and trifluoromethanesulfonic acid, as well as to relatively less-reactive aryl chlorides. A wide range of functionalities on the aromatic ring of the substrates were tolerated under the aminocarbonylation conditions. The catalytic aminocarbonylation was used to prepare the insect repellent N,N-diethyl-3-methylbenzamide as well as a synthetic intermediate of the dihydrofolate reductase inhibitor triazinate.

Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid

The ipso nitration of aryl boronic acid derivatives has been developed using fuming nitric acid as the nitrating agent. This facile procedure provides efficient and chemoselective access to a variety of aromatic nitro compounds. While several activating agents and nitro sources have been reported in the literature for this synthetically useful transformation, this report demonstrates that these processes likely generate a common active reagent, anhydrous HNO3. Kinetic and mechanistic studies have revealed that the reaction order in HNO3 is >2 and indicate that the ?NO2 radical is the active species.

Benzamide derivatives as protein kinase inhibitors

The present invention relates to a benzamide compound having protein kinase inhibitory activity, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing and treating diseases caused by abnormal cell growth containing th

Synthesis method of tertiary amide compound

The invention provides a synthesis method of a tertiary amide compound, which comprises the following steps: reacting acyl chloride and N, N-disubstituted-4-oxopiperidinium salt used as raw materials,tris (2, 2 '-dipyridyl) ruthenium dichloride (II) used as a photosensitizer and triethylamine used as an alkali at room temperature for 3-12h under the protection of N2, and purifying to obtain the tertiary amide compound. The reaction is completed under the illumination condition, the cost is low, and the efficiency is high; the synthesis operation is simple and convenient, the reaction conditions are mild, and a method for synthesizing tertiary amide compounds without using harsh high-temperature heating conditions is developed; N, N-disubstituted-4-oxopiperidinium salt is adopted as a reaction raw material, is relatively stable in property and convenient to store, and is particularly suitable for industrial large-scale production.

Pyrrolopyrimidine compound, pharmaceutical composition containing thereof, and preparation method and applications

The invention relates to a pyrrolopyrimidine compound represented by formula I, a pharmaceutical composition containing thereof, and a preparation method and applications in preventing or treating Weel protein kinase related diseases.

Design, synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors

BTK is an effective target for the treatment of B-cell malignant tumors and autoimmune diseases. In this work, a series of 2-phenyl pyrimidine derivatives were prepared and their preliminary in vitro activities on B-cell leukemia cells as well as the BTK enzyme were determined. The results showed that compound 11g displayed the best inhibitory activity on BTK with an inhibition rate of 82.76% at 100 nM and excellent anti-proliferation activity on three B-cell leukemia lines (IC50 = 3.66 μM, 6.98 μM, and 5.39 μM against HL60, Raji and Ramos, respectively). Besides, the flow cytometry analysis results indicated that 11g inhibited the proliferation of the Raji cells in a dose- and time-dependent manner, and blocked the Ramos cells at the G0/G1 phase, which is in accordance with the positive control ibrutinib. The mechanism investigation demonstrated that 11g could inhibit the phosphorylation of BTK and its downstream substrate phospholipase γ2 (PLCγ2). All these results showed that 11g was a promising lead compound that merited further optimization as a novel class of BTK inhibitor for the treatment of B-cell lymphoblastic leukemia.

SULPHONAMIDES AND COMPOSITIONS THEREOF FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: wherein the variables shown in Formula AA can be as defined anywhere herein. Compounds AA are modulators of NLRP1 and/or NLRP3