5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Name:5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:1272667-52-3
Molecular Formula:C₂₆H₃₁N₇O₂
Molecular Weight:473.578
Hs Code.:

Synonyms:5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Property of 5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Technology Process of 5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 13 articles about 5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272667-53-4
((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methyl methanesulfonate

: 1272667-52-3
5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

: 22428-85-9
4-Methylencyclohexanol

: 1272667-52-3
5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: N-iodo-succinimide / acetonitrile / 20 °C

2: potassium carbonate / acetonitrile / 18 h / 150 °C / Pressure vessel

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 90 °C / Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 0 °C

5: sodium azide / N,N-dimethyl-formamide / 6 h / 80 °C

With N-iodo-succinimide; sodium azide; sodium carbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3685-23-2
cis-4-aminocyclohexane-1-carboxylic acid

: 1272667-52-3
5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 20 °C

1.2: 2 h / 20 °C

1.3: 60 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 20 h / 60 °C

3.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

4.1: ammonium hydroxide / ethanol / 100 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 90 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 1 h / 0 °C

7.1: sodium azide / N,N-dimethyl-formamide / 6 h / 80 °C

With ammonium hydroxide; N-iodo-succinimide; sodium azide; borane-THF; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;