5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Name:5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:1272670-06-0
Molecular Formula:C₂₆H₃₃N₅O₂
Molecular Weight:447.58
Hs Code.:

Synonyms:5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Chemical Property of 5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Technology Process of 5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 14 articles about 5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272667-52-3
5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 1272670-06-0
5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water; at 80 ℃; for 1h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1272670-06-0
5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -10 °C

1.2: 4 h / -10 - 20 °C

2.1: water; oxalic acid / acetone / 3 h / 20 °C

3.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

4.1: N-iodo-succinimide / acetonitrile / 20 °C

5.1: potassium carbonate / acetonitrile / 18 h / 150 °C / Pressure vessel

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 90 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / 1 h / 0 °C

8.1: sodium azide / N,N-dimethyl-formamide / 6 h / 80 °C

9.1: triphenylphosphine / water; tetrahydrofuran / 1 h / 80 °C

With sodium tetrahydroborate; N-iodo-succinimide; n-butyllithium; sodium azide; water; oxalic acid; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 22428-85-9
4-Methylencyclohexanol

: 1272670-06-0
5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / acetonitrile / 20 °C

2: potassium carbonate / acetonitrile / 18 h / 150 °C / Pressure vessel

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 90 °C / Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 0 °C

5: sodium azide / N,N-dimethyl-formamide / 6 h / 80 °C

6: triphenylphosphine / water; tetrahydrofuran / 1 h / 80 °C

With N-iodo-succinimide; sodium azide; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;