2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione
CAS No.:222022-30-2
Molecular Formula:C₂₆H₂₄N₂O₄S
Molecular Weight:460.554
Hs Code.:

Synonyms:2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione

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Chemical Property of 2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione

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Technology Process of 2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione

There total 11 articles about 2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2436-29-5
3-(N-phthaloyl)propionaldehyde

: 5450-75-9
4-methyl-N-(2-phenylethyl)benzenesulfonamide

: 222022-30-2
2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: With trifluoroacetic acid; for 1.5h; Heating;
DOI:10.1016/S0968-0896(01)00017-7

Reference yield:

: 64-04-0
phenethylamine

: 222022-30-2
2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / pyridine / 18 h / 20 °C

2: 90 percent / CF₃COOH / 1.5 h / Heating

With trifluoroacetic acid; In pyridine; 2: Pictet-Spengler cyclization;
DOI:10.1016/S0968-0896(01)00017-7

Reference yield:

: 127413-25-6
N-phenethyl-3-phthalimidopropionamide

: 222022-30-2
2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: P₂O₅; POCl₃ / toluene / 20 h / Heating

2.1: HCl / ethanol / 1 h / 20 °C

2.2: H₂ / PtO₂*H₂O / ethanol / 0.83 h / 25 °C / 2327.17 Torr

3.1: 78 percent / NaHCO₃ / methanol / 1 h / microwave irradiation

4.1: 98 percent / hydrazine monohydrate / ethanol / 18 h / 20 °C

With hydrogenchloride; phosphorus pentoxide; sodium hydrogencarbonate; hydrazine hydrate; trichlorophosphate; In methanol; ethanol; toluene; 1.1: Bischler-Napieralski reaction;
DOI:10.1016/S0968-0896(01)00017-7