2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester
• CAS No.: 866235-10-1
• Molecular Formula: C₁₉H₂₄F₃NO₄
• Molecular Weight: 387.399
• Mol file: 866235-10-1.mol

Synonyms:2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester

Chemical Property of 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester

There total 3 articles about 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

β-cyclohexylalanine (4441-50-3,27527-05-5,55658-63-4,58717-02-5) → 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester (866235-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1: Schotten-Baumann reaction;

DOI:10.1016/j.tetasy.2005.06.037

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester (866235-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1: Schotten-Baumann reaction;

DOI:10.1016/j.tetasy.2005.06.037

Reference yield:

2,2,2-trifluoroethanol (75-89-8) + N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid (119860-59-2) → 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester (866235-10-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1016/j.tetasy.2005.06.037

upstream raw materials:

2,2,2-trifluoroethanol

N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid

β-cyclohexylalanine

benzyl chloroformate

Downstream raw materials:

(S)-2-Benzyloxycarbonylamino-3-cyclohexyl-propionic acid methyl ester