5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide
• CAS No.: 201280-39-9
• Molecular Formula: C₂₁H₁₇N₅O₃
• Molecular Weight: 387.398

Synonyms:5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide

Chemical Property of 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide

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Technology Process of 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide

There total 2 articles about 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

benzaldehyde (100-52-7) + 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid hydrazide (174599-87-2) → 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide (201280-39-9)

Guidance literature:

With piperidine; In 1,4-dioxane; for 2h; Heating;

DOI:10.1080/10426509708043501

Reference yield:

ethyl 5-cyano-1-(4-methoxyphenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (123565-82-2) → 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide (201280-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / NH₂NH₂*H₂O / ethanol; dimethylformamide / 0.5 h / Heating

2: 43 percent / piperidine / dioxane / 2 h / Heating

With piperidine; hydrazine hydrate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

DOI:10.1080/10426509708043501

Reference yield: 85.0%

benzaldehyde (100-52-7) + 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide (201280-39-9) → 2-(4-Methoxy-phenyl)-3,8-dioxo-6-phenyl-7-{[1-phenyl-meth-(E)-ylidene]-amino}-2,3,7,8-tetrahydro-pyrido[3,4-c]pyridazine-4-carbonitrile

Guidance literature:

With piperidine; In 1,4-dioxane; for 2h; Heating;

DOI:10.1080/10426509708043501

upstream raw materials:

benzaldehyde

5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid hydrazide

ethyl 5-cyano-1-(4-methoxyphenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

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