2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole

Base Information

• Chemical Name: 2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole
• CAS No.: 187937-70-8
• Molecular Formula: C₃₄H₃₇N₃O₂
• Molecular Weight: 519.687
• Mol file: 187937-70-8.mol

Synonyms:2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole

Chemical Property of 2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole

There total 1 articles about 2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C,N-diphenylnitrone (201024-81-9) + (E)-1-((4R,7S)-7-Isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-indazol-2-yl)-but-2-en-1-one → 2-(3'R,4'S,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole (1212284-31-5) + 2-(3'R,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole (1212284-31-5) + 2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole (187937-70-8,1212284-31-5)

Guidance literature:

With zinc dibromide; In tetrahydrofuran; for 1.5h; Yield given. Title compound not separated from byproducts; Heating;

DOI:10.3987/COM-96-S19

Reference yield: 86.0%

2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole (187937-70-8,1212284-31-5) → 2-[2,3-trans-2-(1-hydroxyethyl)-3-anilino-3-phenyl]propanoyl-3-phenyl-l-menthopyrazole

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.3987/COM-96-S19

Reference yield: 74.0%

methanol (67-56-1) + 2-(3'S,4'R,5'S-2',3'-diphenyl-5'-methylisoxazolidine-4'-carbonyl)-3-phenyl-l-menthopyrazole (187937-70-8,1212284-31-5) → methyl 3,4-trans-4,5-trans-5-methyl-2,3-diphenylisoxazolidine-4-carboxylate (19380-27-9,115939-23-6,115939-24-7)

Guidance literature:

With sodium methylate; for 0.5h; Ambient temperature;

DOI:10.3987/COM-96-S19

upstream raw materials:

C,N-diphenylnitrone

Downstream raw materials:

methyl 3,4-trans-4,5-trans-5-methyl-2,3-diphenylisoxazolidine-4-carboxylate