methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate

Base Information

Chemical Name:methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate
CAS No.:154136-25-1
Molecular Formula:C₂₂H₂₇NO₅
Molecular Weight:385.46
Hs Code.:

Synonyms:methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate

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Technology Process of methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate

There total 14 articles about methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 155396-65-9
(2R,3S)-2-benzyloxy-3-tert-butoxy-carbonylamino-3-phenylpropanoic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 154136-25-1
methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate

Guidance literature:: In methanol; toluene;

Reference yield: 64.0%

: 67-56-1
methanol

: 154136-24-0
S-tert-butyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanethioate

: 154136-25-1
methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate

Guidance literature:: With thallium(III) nitrate; at 27 ℃;
DOI:10.1016/S0040-4020(01)81916-5

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 154136-25-1
methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / H₂ / Pd(OH)2/C / methanol / 25 °C / 3000.2 Torr

2: CrO₃*2 pyridine / CH₂Cl₂ / 0.42 h / 25 °C

3: Br₂, aq. NaHCO₃

With hydrogen; bromine; dipyridine chromium trioxide; sodium hydrogencarbonate; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1039/CC9960000331