2-methyl-3-(morpholin-4-yl)-1-phenylpropan-1-one

Base Information

• Chemical Name: 2-methyl-3-(morpholin-4-yl)-1-phenylpropan-1-one
• CAS No.: 22386-00-1
• Molecular Formula: C14H19 N O2
• Molecular Weight: 233.31
• Mol file: 22386-00-1.mol

Synonyms:Propiophenone,2-methyl-3-morpholino- (8CI); 3-Morpholino-2-methylpropiophenone

Chemical Property of 2-methyl-3-(morpholin-4-yl)-1-phenylpropan-1-one

Chemical Property:

• Vapor Pressure: 1.73E-05mmHg at 25°C
• Boiling Point: 364.1°C at 760 mmHg
• Flash Point: 174°C
• Density: 1.065g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-3-(morpholin-4-yl)-1-phenylpropan-1-one

There total 4 articles about 2-methyl-3-(morpholin-4-yl)-1-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + N-methoxy-N-methylbenzamide (6919-61-5) + isopropenylmagnesium bromide (13291-18-4) → 2-methyl-3-morpholino-1-phenylpropan-1-one (22386-00-1)

Guidance literature:

N-methoxy-N-methylbenzamide; isopropenylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1.16667h;

morpholine; In tetrahydrofuran; water; at 20 ℃; for 0.333333h; Further stages.;

DOI:10.1021/jo0057497

Reference yield: 57.17%

morpholine (110-91-8,99108-56-2) + 2-bromo-2-methyl-1-phenyl-propan-1-one (10409-54-8) → 2-methyl-3-morpholino-1-phenylpropan-1-one (22386-00-1)

Guidance literature:

With silver carbonate; In dimethyl sulfoxide; at 70 ℃; for 0.5h;

DOI:10.1002/ejoc.201901649

Reference yield: 54.0%

4-(benzoyloxy)morpholine (5765-65-1) + 2-methyl-1-phenylprop-2-en-1-one (769-60-8) → 2-methyl-3-morpholino-1-phenylpropan-1-one (22386-00-1)

Guidance literature:

With copper(l) iodide; In dichloromethane; at 25 ℃; for 40h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1002/cjoc.202000105

upstream raw materials:

formaldehyd

morpholinium hydrobromide

1-phenyl-propan-1-one

morpholine

Downstream raw materials:

N-(2-methyl-3-morpholin-4-yl-1-phenyl-propyl)-acetamide

2-methyl-3-morpholin-4-yl-1-phenyl-propan-1-ol