(R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:(R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester
CAS No.:204637-81-0
Molecular Formula:C₂₉H₃₆O₆
Molecular Weight:480.601
Hs Code.:

Synonyms:(R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

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Chemical Property of (R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Chemical Property:

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Technology Process of (R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

There total 7 articles about (R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 204637-80-9
(R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 1-tert-butyl ester

: 204637-81-0
(R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 22 ℃; for 24h; Yield given;
DOI:10.1016/S0960-894X(97)10179-2

Reference yield:

: 100-39-0
benzyl bromide

: 204637-81-0
(R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃ / ethyl acetate / Heating

2: pyridine

3: NaH

With sodium hydride; triethylamine; In pyridine; ethyl acetate;
DOI:10.1016/S0960-894X(97)00416-2

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 204637-81-0
(R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 2.) THF, 3 h

2: Cs₂CO₃ / dimethylformamide / 24 h / 22 °C

With caesium carbonate; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)10179-2