204637-80-9

Upstream product

• 501-53-1 benzyl chloroformate 
• 204637-77-4 (R)-2-cyclopentyl-methyl-succinic acid 4-tert-butyl ester 

Downstream Products

• 204637-85-4 1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine 
• 204637-86-5 Cipemastat 
• 174265-38-4 cipemastat 
• 204637-83-2 (R)-3-Benzyloxycarbonyl-3-tert-butoxycarbonyl-2-cyclopentylmethyl-4-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-butyric acid benzyl ester 
• 204637-81-0 (R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester 

Relevant academic research and scientific papers

Alkylation of succinates: Synthesis of Ro 32-3555

A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.