{2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane

Base Information

Chemical Name:{2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane
CAS No.:720712-34-5
Molecular Formula:C₃₃H₄₂O₄Si
Molecular Weight:530.78
Hs Code.:

Synonyms:{2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane

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Chemical Property of {2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of {2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane

There total 4 articles about {2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 135500-31-1,127598-16-7
(1R,2S)-2-phenylcyclohexyl vinyl ether

: phenylmagnesium bromide

: 720712-25-4
carbonic acid tert-butyl ester 2-formyl-4-methoxy-5-(2-trimethylsilanyl-ethoxy)-phenyl ester

: 720712-34-5
{2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane

Guidance literature:: In diethyl ether; at -78 - 20 ℃; for 3h;
DOI:10.1055/s-2004-822888 DOI:10.1021/jo048703c

Reference yield:

: 51061-83-7
2,4-dihydroxy-5-methoxybenzaldehyde

: 720712-34-5
{2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

2: Hunig's base; DMAP / CH₂Cl₂

3: 83 percent / diethyl ether / 3 h / -78 - 20 °C

With dmap; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jo048703c

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 720712-34-5
{2-[(2S,4R)-6-Methoxy-4-phenyl-2-((1R,2S)-2-phenyl-cyclohexyloxy)-chroman-7-yloxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

2: Hunig's base; DMAP / CH₂Cl₂

3: 83 percent / diethyl ether / 3 h / -78 - 20 °C

With dmap; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jo048703c