(R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

Base Information

Chemical Name:(R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol
CAS No.:720712-37-8
Molecular Formula:C₂₂H₃₂O₄Si
Molecular Weight:388.579
Hs Code.:

Synonyms:(R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

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Chemical Property of (R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

Chemical Property:

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Technology Process of (R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

There total 7 articles about (R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 828933-81-9
2-((R)-3-Hydroxy-1-phenyl-propyl)-4-methoxy-5-(2-trimethylsilanyl-ethoxy)-phenol

: 720712-37-8
(R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

Guidance literature:: In diethyl ether; for 12h;
DOI:10.1021/jo048703c

Reference yield:

: 51061-83-7
2,4-dihydroxy-5-methoxybenzaldehyde

: 720712-37-8
(R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

2: Hunig's base; DMAP / CH₂Cl₂

3: 83 percent / diethyl ether / 3 h / -78 - 20 °C

4: 91 percent / H₂O; CSA / acetonitrile; tetrahydrofuran / 6 h / 100 °C

5: 82 percent / LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

6: 90 percent / diethyl ether / 12 h

With dmap; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jo048703c

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 720712-37-8
(R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

2: Hunig's base; DMAP / CH₂Cl₂

3: 83 percent / diethyl ether / 3 h / -78 - 20 °C

4: 91 percent / H₂O; CSA / acetonitrile; tetrahydrofuran / 6 h / 100 °C

5: 82 percent / LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

6: 90 percent / diethyl ether / 12 h

With dmap; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jo048703c