methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate

Base Information

Chemical Name:methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate
CAS No.:1357268-73-5
Molecular Formula:C₁₆H₂₁F₂NO₄S
Molecular Weight:361.41
Hs Code.:

Synonyms:methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate

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Chemical Property of methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate

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Technology Process of methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate

There total 2 articles about methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 55212-79-8,15424-17-6
3-Pyrrolidino-2-butensaeure-methylester

: 536975-50-5
[difluoro(phenylsulfonyl)methyl](trimethyl)silane

: 1357268-73-5
methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate

Guidance literature:: 3-Pyrrolidino-2-butensaeure-methylester; With potassium hydrogen difluoride; trifluoroacetic acid; In acetonitrile; at 0 ℃; for 0.0833333h; Inert atmosphere;

[difluoro(phenylsulfonyl)methyl](trimethyl)silane; In acetonitrile; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jo202669w

Reference yield:

: 80351-58-2
[(bromodifluoromethyl)sulfonyl]benzene

: 1357268-73-5
methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 - -70 °C / Inert atmosphere

2.1: potassium hydrogen difluoride; trifluoroacetic acid / acetonitrile / 0.08 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

With n-butyllithium; potassium hydrogen difluoride; trifluoroacetic acid; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jo202669w