80351-58-2

Basic information

• Product Name: Benzene, [(bromodifluoromethyl)sulfonyl]-
• CAS NO: 80351-58-2
• Molecular Formula: C7H5BrF2O2S
• Molecular Weight: 271.082
• Mol File: 80351-58-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, [(bromodifluoromethyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(bromodifluoromethyl)sulfonyl]-(80351-58-2)
• EPA Substance Registry System: Benzene, [(bromodifluoromethyl)sulfonyl]-(80351-58-2)

Safety Data

• Hazardous Substances Data: 80351-58-2(Hazardous Substances Data)

Usage

General Description

Benzene, [(bromodifluoromethyl)sulfonyl]- is a chemical compound with the molecular formula C7H4BrF2O2S. It is a colorless liquid with a molecular weight of 261.07 g/mol. Benzene, [(bromodifluoromethyl)sulfonyl]- is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a solvent and as a reagent in organic synthesis. Benzene, [(bromodifluoromethyl)sulfonyl]- is considered to have low toxicity, but it may cause irritation to the skin, eyes, and respiratory system upon exposure. It should be stored and handled with proper safety precautions to prevent any potential health hazards.

Upstream product

• 1535-65-5 difluoromethyl phenyl sulfone 
• 108-98-5 thiophenol 
• 930-69-8 sodium thiophenolate 
• 78031-08-0 [(bromodifluoromethyl)sulfanyl]benzene 

Downstream Products

• 861721-49-5 (E)-1,1-difluoro-4-phenyl-1-(phenylsulfonyl)but-3-en-2-ol 
• 1421521-01-8 (E)-1-[3,3-difluoro-3-(phenylsulfonyl)prop-1-en-1-yl]-4-fluorobenzene 
• 1421521-20-1 2-(difluoro(phenylsulfonyl)methyl)thiophene 
• 1421521-21-2 3-[difluoro-(phenylsulfonyl)methyl]thiophene 
• 1421521-02-9 (E)-1-chloro-3-[3,3-difluoro-3-(phenylsulfonyl)prop-1-en-1-yl]benzene 
• 1421521-03-0 (E)-1-[3,3-difluoro-3-(phenylsulfonyl)prop-1-en-1-yl]-3-fluorobenzene 
• 1421521-04-1 (E)-1-[3,3-difluoro-3-(phenylsulfonyl)prop-1-en-1-yl]-3-nitrobenzene 
• 1380394-71-7 (E)-[3,3-difluoro-3-(phenylsulfonyl)prop-1-en-1-yl]benzen 
• 1380394-69-3 (E)-1-[3,3-difluoro-3-(phenylsulfonyl)prop-1-en-1-yl]-4-methylbenzene 
• 1421521-05-2 (E)-methyl 4-[3,3-difluoro-3-(phenylsulfonyl)prop-1-en-1-yl]benzoate 
• 861721-51-9 1-(benzenesulfonyl)difluoromethyl-3-phenylpropanol 
• 536975-50-5 [difluoro(phenylsulfonyl)methyl](trimethyl)silane 

Relevant articles and documents

An easier and quicker access to (benzenesulfonyl)difluoromethanesulfenamide reagent

(Benzenesulfonyl)difluoromethanesulfenamide (PhSO2-BB12H) is an interesting reagent to lead to various fluoroalkylselenotated molecules. This compound is obtained from [(benzenesulfonyl)difluoromethyl]trimethylsilane. Herein, a new process in two steps, w

Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent

The (benzenesulfonyl)difluoromethylsulfanyl (PhSO2CF2S) group is a valuable substituent with specific properties which can provide access to new applications of fluoroalkylthiolated compounds. Direct introduction of this moiety can be performed by in an electrophilic manner by using a new shelf-stable reagent, namely a (benzenesulfonyl)difluoromethanesulfenamide. Furthermore, mild magnesium-mediated reduction of the PhSO2CF2S group leads to a facile synthesis of difluoromethylthiolated molecules and their deuterated analogs. Chameleon-like reactivity: (Benzenesulfonyl)difluoromethanesulfenamide was developed as a new, shelf-stable reagent for the introduction of the PhSO2CF2S group into organic molecules (see scheme). The versatility of the PhSO2 moiety also provides an entry into reductive deuterations.

Palladium-mediated heck-type reactions of [(Bromodifluoromethyl)sulfonyl] benzene: Synthesis of α-alkenyl- and α-heteroaryl-substituted α,α-difluoromethyl phenyl sulfones

Palladium-catalyzed Heck-type reactions of [(bromodifluoromethyl)sulfonyl] benzene (1) with styrene derivatives and heteroaromatic compounds successfully gave α-alkenyl- and α-heteroaryl-substituted α,α- difluoromethyl phenyl sulfones, respectively. Palladium-catalyzed Heck-type reactions of [(bromodifluoromethyl)sulfonyl]benzene (1) are reported. Both styrene derivatives and heteroaromatic compounds gave PhSO2CF 2-substituted products in moderate to good yields.