3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid

Base Information

Chemical Name:3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid
CAS No.:1455089-85-6
Molecular Formula:C₂₆H₂₂FN₃O₅
Molecular Weight:475.476
Hs Code.:

Synonyms:3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid

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Chemical Property of 3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid

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Technology Process of 3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid

There total 11 articles about 3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392841-25-6
3-amino-2,2-dimethylpropionic acid TFA salt

: 1455094-16-2
1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

: 1455089-85-6
3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid

Guidance literature:: With sodium methylate; In methanol; at 150 ℃; for 6h; Microwave irradiation;

Reference yield:

: 1455091-04-9
2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

: 1455089-85-6
3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

5: sodium methylate / methanol / 6 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; caesium carbonate; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

: 1455089-85-6
3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / ethanol / 20 h / 20 °C

2: sodium hydroxide / methanol; water / 6 h / 20 °C

3: dichloromethane / 3 h / 20 °C

4: sodium methylate / methanol / 6 h / 150 °C / Microwave irradiation

With hydrogen; sodium methylate; sodium hydroxide; In methanol; ethanol; dichloromethane; water;