1223404-90-7

Basic information

• Product Name: (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine
• Synonyms: Larotrectinib DFP-PNPP Impurity;Larotrectinib Impurity 3（Larotrectinib DFP-PNPP Impurity）;(R)-5-(2-(2,5-Difluorophenyl)-1-pyrrolidinyl)-3-nitropyrazolo[1,5-a]pyrimidine;(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine;(2R)-2-(2,5-difluorophenyl)-1-{3-nitropyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine;5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]-3-nitr opyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyrimidine, 5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]-3-nitro-
• CAS NO: 1223404-90-7
• Molecular Formula: C₁₆H₁₃F₂N₅O₂
• Molecular Weight: 345.3
• Mol File: 1223404-90-7.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.58±0.1 g/cm3(Predicted)
• PKA: -0.73±0.40(Predicted)
• CAS DataBase Reference: (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine(1223404-90-7)
• EPA Substance Registry System: (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine(1223404-90-7)

Safety Data

• Hazardous Substances Data: 1223404-90-7(Hazardous Substances Data)

Usage

General Description

"(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine" is a complex organic compound that can be classified as a pyrimidine derivative. As a derivative of pyrimidine, it has potential to exhibit useful biological activity. The presence of the difluorophenyl and pyrrolidinyl group potentially suggests activity as a receptor binding agent or enzyme inhibitor. In addition, the nitropyrazolopyrimidine moiety could also show interaction with biological systems. Its chiral R-configuration indicates its stereochemistry which can affect the compound's bioactivity. More specific information would require detailed scientific research, including lab tests, to determine its precise properties and potential applications.

Upstream product

• 1218935-60-4 (2R)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride 
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• 29274-22-4 4H,5H-pyrazolo[1,5-a]pyrimidine-5-one 
• 1218935-59-1 (R)-(+)-2-(2,5-difluorophenyl)pyrrolidine 
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• 1919868-77-1 (R)-(+)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate 
• 1443623-92-4 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole 
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• 1919868-77-1 (R)-2-(2,5-difluorophenyl)-pyrrolidine (R)-2-hydroxy-succinate 
• 1919868-75-9 3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one 
• 1223404-89-4 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine 

Downstream Products

• 1223404-88-3 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine 
• 2135871-21-3 phenyl (5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3,3a-dihydropyrazolo[1,5-a]pyrimidin-3-yl)carbamate 
• 1223405-08-0 (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate 
• 1223403-58-4 (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide 

Relevant articles and documents

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