4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide

Base Information

• Chemical Name: 4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide
• CAS No.: 1431533-42-4
• Molecular Formula: C₁₇H₁₅F₂NO₄
• Molecular Weight: 335.307
• Mol file: 1431533-42-4.mol

Synonyms:4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide

Chemical Property of 4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide

There total 2 articles about 4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid (1343436-42-9) + 4-aminoresorcinol hydrochloride (34781-86-7) → 4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide (1431533-42-4)

Guidance literature:

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid; 4-aminoresorcinol hydrochloride; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-aminoresorcinol hydrochloride; In tetrahydrofuran;

Reference yield:

3,4,5-trifluorobenzoic acid (121602-93-5,255875-61-7) → 4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide (1431533-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 0.5 h / 20 °C

1.3: 0.67 h / 60 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 20 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide (1431533-42-4) → 2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-ol (1431533-43-5)

Guidance literature:

With triethylamine; triphenylphosphine; In acetonitrile; at 20 - 80 ℃; for 2.25h;

upstream raw materials:

3,4,5-trifluorobenzoic acid

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid

4-aminoresorcinol hydrochloride

Downstream raw materials:

tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-ol