N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Base Information

• Chemical Name: N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide
• CAS No.: 1431531-37-1
• Molecular Formula: C₂₂H₂₂F₂N₂O₄
• Molecular Weight: 416.424
• Mol file: 1431531-37-1.mol

Synonyms:N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Chemical Property of N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

There total 6 articles about N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate (1431533-44-6) + acetic anhydride (108-24-7) → N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide (1431531-37-1)

Guidance literature:

tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.166667h;

acetic anhydride; With pyridine; at 20 ℃; for 0.25h;

Reference yield:

3,4,5-trifluorobenzoic acid (121602-93-5,255875-61-7) → N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide (1431531-37-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 0.5 h / 20 °C

1.3: 0.67 h / 60 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 20 °C

3.1: triphenylphosphine; triethylamine / acetonitrile / 2.25 h / 20 - 80 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 16 h / 20 °C

5.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C

5.2: 0.25 h / 20 °C

With hydrogenchloride; oxalyl dichloride; di-isopropyl azodicarboxylate; sodium hydride; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid (1343436-42-9) → N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide (1431531-37-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 20 °C

2.1: triphenylphosphine; triethylamine / acetonitrile / 2.25 h / 20 - 80 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 16 h / 20 °C

4.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C

4.2: 0.25 h / 20 °C

With hydrogenchloride; oxalyl dichloride; di-isopropyl azodicarboxylate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

3,4,5-trifluorobenzoic acid

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid

4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide

2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-ol