4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid

Base Information

• Chemical Name: 4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid
• CAS No.: 1343436-42-9
• Molecular Formula: C₁₁H₁₀F₂O₃
• Molecular Weight: 228.195
• Mol file: 1343436-42-9.mol

Synonyms:4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid

Chemical Property of 4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-(Cyclopropylmethoxy)-3,5-difluorobenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid

There total 1 articles about 4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclopropylmethanol (2516-33-8) + 3,4,5-trifluorobenzoic acid (121602-93-5,255875-61-7) → 4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid (1343436-42-9)

Guidance literature:

Cyclopropylmethanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

3,4,5-trifluorobenzoic acid; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

With potassium carbonate; methyl iodide; In N,N-dimethyl-formamide; at 60 ℃; for 0.666667h;

Reference yield:

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid (1343436-42-9) + 4-aminoresorcinol hydrochloride (34781-86-7) → 4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide (1431533-42-4)

Guidance literature:

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid; 4-aminoresorcinol hydrochloride; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-aminoresorcinol hydrochloride; In tetrahydrofuran;

Reference yield:

2,4-bis(benzyloxy)-3-fluoroaniline (1431533-13-9) + 4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid (1343436-42-9) → N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-3,5-difluorobenzamide (1431533-28-6)

Guidance literature:

4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2,4-bis(benzyloxy)-3-fluoroaniline; With pyridine; at 20 ℃; for 0.5h;

upstream raw materials:

Cyclopropylmethanol

3,4,5-trifluorobenzoic acid

Downstream raw materials:

2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-ol

tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

N-((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

4-(cyclopropylmethoxy)-N-(2,4-dihydroxyphenyl)-3,5-difluorobenzamide

Refernces