tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate
CAS No.:1431533-44-6
Molecular Formula:C₂₅H₂₈F₂N₂O₅
Molecular Weight:474.505
Hs Code.:

Synonyms:tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

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Chemical Property of tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

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Technology Process of tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

There total 4 articles about tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431533-43-5
2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-ol

: 79069-13-9
(S)-2-t-butoxycarbonylaminopropan-1-ol

: 1431533-44-6
tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; at 20 ℃; for 16h;

Reference yield:

: 121602-93-5,255875-61-7
3,4,5-trifluorobenzoic acid

: 1431533-44-6
tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 0.5 h / 20 °C

1.3: 0.67 h / 60 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 20 °C

3.1: triphenylphosphine; triethylamine / acetonitrile / 2.25 h / 20 - 80 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 16 h / 20 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; sodium hydride; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1343436-42-9
4-(cyclopropylmethoxy)-3,5-difluorobenzoic acid

: 1431533-44-6
tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 20 °C

2: triphenylphosphine; triethylamine / acetonitrile / 2.25 h / 20 - 80 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 16 h / 20 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;