lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

Base Information

Chemical Name:lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate
CAS No.:1312009-38-3
Molecular Formula:C₂₁H₁₈ClN₄O₅*Li
Molecular Weight:448.792
Hs Code.:

Synonyms:lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

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Chemical Property of lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

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Technology Process of lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

There total 13 articles about lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186407-74-9
4-bromoindazole

: 1312009-38-3
lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 70 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 2.17 h / 20 °C / Reflux

4.1: triethylamine / N,N-dimethyl-formamide / 40 h / 120 °C / Cooling with ice

5.1: lithium diisopropyl amide; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: -78 - -40 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 75 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1312009-02-1
ethyl 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

: 1312009-38-3
lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 75 ℃; for 3h; Inert atmosphere;

Reference yield:

: 55289-36-6
3-bromo-2-methylaniline

: 1312009-38-3
lithium 3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloroform / 5 - 20 °C

1.2: 20 - 68 °C

1.3: 2 h / 50 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 70 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

4.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 2.17 h / 20 °C / Reflux

5.1: triethylamine / N,N-dimethyl-formamide / 40 h / 120 °C / Cooling with ice

6.1: lithium diisopropyl amide; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 - -40 °C

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 75 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; N,N-dimethyl-formamide; acetonitrile;