2-[(2E)-2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1-yl]-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide hydrochloride (1:1)

Base Information

• Chemical Name: 2-[(2E)-2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1-yl]-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide hydrochloride (1:1)
• CAS No.: 117651-71-5
• Molecular Formula: C₂₀H₂₆N₄O*ClH
• Molecular Weight: 374.914
• Mol file: 117651-71-5.mol

Synonyms:1H-Benzimidazole-1-acetamide,2,3-dihydro-2-imino-3-methyl-N-tricyclo[3.3.1.13,7]dec-1-yl-, monohydrochloride(9CI); NSC 646476

Chemical Property of 2-[(2E)-2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1-yl]-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide hydrochloride (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2E)-2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1-yl]-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide hydrochloride (1:1)

There total 2 articles about 2-[(2E)-2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1-yl]-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(1-adamantyl)-2-chloroacetamide (5689-59-8) + 2-Amino-1-methylbenzimidazole (1622-57-7) → N-Adamantan-1-yl-2-(2-imino-3-methyl-2,3-dihydro-benzoimidazol-1-yl)-acetamide; hydrochloride (117651-71-5)

Guidance literature:

In acetone; for 30h; Heating;

DOI:10.1007/BF00763525

Reference yield:

1-Adamantanamine (768-94-5) → N-Adamantan-1-yl-2-(2-imino-3-methyl-2,3-dihydro-benzoimidazol-1-yl)-acetamide; hydrochloride (117651-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 86.7 percent / benzene / 3 h / 20 - 25 °C

2: 89 percent / acetone / 30 h / Heating

In acetone; benzene;

DOI:10.1007/BF00763525

upstream raw materials:

N-(1-adamantyl)-2-chloroacetamide

2-Amino-1-methylbenzimidazole

1-Adamantanamine

Refernces