methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

Base Information

Chemical Name:methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate
CAS No.:121060-55-7
Molecular Formula:C₁₉H₁₆N₂O₃S
Molecular Weight:352.414
Hs Code.:

Synonyms:methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

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Technology Process of methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

There total 10 articles about methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

: 67-56-1
methanol

: 121060-50-2
[2-(4-Methoxy-phenyl)-benzo[d]imidazo[2,1-b]thiazol-3-yl]-acetic acid

: 121060-55-7
methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

Guidance literature:: With sulfuric acid; In chloroform; for 5h; Heating;
DOI:10.1248/cpb.36.4760

Reference yield: 77.0%

: 32804-66-3
methyl 3-butynoate

: 54079-72-0
N-(4-methoxybenzylidene)benzothiazol-2-amine

: 121060-55-7
methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

Guidance literature:: With copper(l) iodide; silica gel; at 200 ℃; for 4.1h; under 11400.8 Torr; Flow reactor; Inert atmosphere;
DOI:10.1021/acs.joc.7b01762

Reference yield:

: 136-95-8,102337-98-4,84293-42-5
2-amino-benzthiazole

: 121060-55-7
methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1: butan-2-one / 4 h / 50 - 55 °C

2: hydrocholric acid / 2-methoxy-ethanol / 5 h / 120 - 130 °C

3: 83 percent / acetic acid / dioxane / 5 h / 70 - 80 °C

4: 75.5 percent / CH₂Cl₂; acetonitrile / 2 h / Heating

5: 62.1 percent / 2-methoxy-ethanol / 5 h / Heating

6: 42.8 percent / aq. sodium hydroxide / 2-methoxy-ethanol / 48 h / Heating

7: 95.1 percent / sulfuric acid / CHCl₃ / 5 h / Heating

With hydrogenchloride; sodium hydroxide; sulfuric acid; acetic acid; In 1,4-dioxane; dichloromethane; chloroform; 2-methoxy-ethanol; acetonitrile; butanone;
DOI:10.1248/cpb.36.4760