2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate

Base Information

• Chemical Name: 2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate
• CAS No.: 1273018-09-9
• Molecular Formula: C₁₉H₁₄Cl₃NO₂
• Molecular Weight: 394.685
• Mol file: 1273018-09-9.mol

Synonyms:2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate

Chemical Property of 2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate

There total 3 articles about 2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl acetate (1265071-88-2) → 2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate (1273018-09-9)

Guidance literature:

With P,P-dichlorophenylphosphine oxide; at 100 ℃; for 2h; Neat (no solvent);

DOI:10.1016/j.bmc.2011.01.006

Reference yield:

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → 2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate (1273018-09-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.42 h / 0 °C

1.2: 0 - 20 °C

1.3: 24 h / 20 °C

2.1: pyridine / 20 °C

3.1: P,P-dichlorophenylphosphine oxide / 2 h / 100 °C / Neat (no solvent)

With pyridine; P,P-dichlorophenylphosphine oxide; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/j.bmc.2011.01.006

Reference yield:

6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one (1046154-83-9) → 2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate (1273018-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 °C

2: P,P-dichlorophenylphosphine oxide / 2 h / 100 °C / Neat (no solvent)

With pyridine; P,P-dichlorophenylphosphine oxide;

DOI:10.1016/j.bmc.2011.01.006

upstream raw materials:

6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one

2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl acetate

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

Downstream raw materials:

2-[6-chloro-4-(2-chlorophenyl)-2-methoxyquinolin-3-yl]ethanol

2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]-ethanol

2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate

3-(2-azidoethyl)-2,6-dichloro-4-(2-chlorophenyl)quinoline