2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate

Base Information

• Chemical Name: 2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate
• CAS No.: 1273018-12-4
• Molecular Formula: C₁₈H₁₄Cl₃NO₃S
• Molecular Weight: 430.739
• Mol file: 1273018-12-4.mol

Synonyms:2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate

Chemical Property of 2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate

There total 5 articles about 2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]-ethanol (1273018-11-3) + methanesulfonyl chloride (124-63-0) → 2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate (1273018-12-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2011.01.006

Reference yield:

6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one (1046154-83-9) → 2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate (1273018-12-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 20 °C

2: P,P-dichlorophenylphosphine oxide / 2 h / 100 °C / Neat (no solvent)

3: ammonium acetate; water / methanol / Reflux

4: triethylamine / dichloromethane / 0 - 20 °C

With pyridine; P,P-dichlorophenylphosphine oxide; ammonium acetate; water; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2011.01.006

Reference yield:

2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl acetate (1265071-88-2) → 2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]ethylmethanesulfonate (1273018-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: P,P-dichlorophenylphosphine oxide / 2 h / 100 °C / Neat (no solvent)

2: ammonium acetate; water / methanol / Reflux

3: triethylamine / dichloromethane / 0 - 20 °C

With P,P-dichlorophenylphosphine oxide; ammonium acetate; water; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2011.01.006

upstream raw materials:

6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl)quinolin-2(1H)-one

2-[6-chloro-4-(2-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl acetate

2-(2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl)ethylacetate

2-[2,6-dichloro-4-(2-chlorophenyl)quinolin-3-yl]-ethanol

Downstream raw materials:

3-(2-azidoethyl)-2,6-dichloro-4-(2-chlorophenyl)quinoline

2-azido-3-(2-azidoethyl)-6-chloro-4-(2-chlorophenyl)quinoline