methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate

Base Information

• Chemical Name: methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate
• CAS No.: 1031883-62-1
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 1031883-62-1.mol

Synonyms:methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate

Chemical Property of methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate

There total 1 articles about methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R)-4-[(4-methoxybenzyl)oxy]piperidin-2-one (1031883-61-0) + methyl chloroformate (79-22-1) → methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate (1031883-62-1)

Guidance literature:

(R)-4-[(4-methoxybenzyl)oxy]piperidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 ℃; for 4h; Further stages.;

DOI:10.1002/ejoc.200700849

Reference yield: 85.0%

methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate (1031883-62-1) + chlorophosphoric acid diphenyl ester (2524-64-3) → C27H28NO8P (1169758-58-0)

Guidance literature:

methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 1.5h; Inert atmosphere;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; toluene; at -78 ℃; for 1h;

DOI:10.1055/s-0028-1088202

Reference yield:

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate (1031883-62-1) → C16H18F3NO7S (1031883-72-3)

Guidance literature:

methyl (R)-4-[(4-methoxybenzyl)oxy]-2-oxopiperidine-1-carboxylate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 1.5h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; toluene; at -78 ℃; for 1h; Further stages.;

DOI:10.1002/ejoc.200700849

upstream raw materials:

(R)-4-[(4-methoxybenzyl)oxy]piperidin-2-one

methyl chloroformate

Downstream raw materials:

C₁₆H₁₈F₃NO₇S

C₂₇H₂₈NO₈P