3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

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Chemical Name:3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide
CAS No.:1262786-23-1
Molecular Formula:C₃₂H₃₅N₅O₂S
Molecular Weight:553.728
Hs Code.:

Synonyms:3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

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Chemical Property of 3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

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Technology Process of 3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

There total 6 articles about 3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1262786-55-9
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

: 56542-67-7
3-cyanobenzene sulfonyl chloride

: 1262786-23-1
3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 5292-53-5
diethyl benzalmalonate

: 1262786-23-1
3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / ethanol / 18 h / 70 °C

2.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C / Inert atmosphere

5.1: hydrogen; ammonia / Raney Nickel / ethanol; water / 18 h / 2585.81 Torr / Fischer-Porter apparatus

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With lithium borohydride; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; Raney Nickel; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 29940-88-3
4-oxo-2-phenyl-butyronitrile

: 1262786-23-1
3-cyano-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: hydrogen; ammonia / Raney Nickel / ethanol; water / 18 h / 2585.81 Torr / Fischer-Porter apparatus

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; Raney Nickel; In ethanol; dichloromethane; water;