16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene

Base Information

• Chemical Name: 16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene
• CAS No.: 18011-92-2
• Molecular Formula: C₂₁H₃₀O₄
• Molecular Weight: 346.467

Synonyms:16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene

Chemical Property of 16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene

Chemical Property:

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Technology Process of 16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene

There total 1 articles about 16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + estrone 3-methyl ether (1624-62-0) → estradiol 3-methyl ether, 17-ol (1035-77-4,2445-32-1,2919-56-4,3434-76-2,3855-62-7,4896-45-1,6570-46-3,6888-38-6,14088-14-3,15426-93-4,16994-40-4,17021-78-2,17337-41-6,19115-71-0,25089-52-5,27984-64-1,51606-70-3,53776-51-5,54274-76-9,55902-77-7,55923-99-4,80374-08-9,90025-05-1,94535-16-7) + 16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene (18011-92-2) + 16,16-Bis(hydroxymethyl)-3-methoxyestra-1,3,5(10)-trien-17-one (18120-33-7)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 45 ℃; for 6h;

DOI:10.1055/s-1985-31152

Reference yield: 69.0%

16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene (18011-92-2) + O-phenyl phosphorodichloridate (770-12-7) → C27H33O6P + C27H33O6P (1197180-93-0) + C27H33O6P (1197180-94-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Reflux; Inert atmosphere;

DOI:10.2174/157017809788489927

Reference yield: 55.0%

P,P-dichlorophenylphosphine oxide (824-72-6) + 16,16-bis(hydroxymethyl)-17β-hydroxy-3-methoxyestra-1,3,5(10)-triene (18011-92-2) → C27H33O5P

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Reflux; Inert atmosphere;

DOI:10.2174/157017809788489927

upstream raw materials:

formaldehyd

estrone 3-methyl ether

Downstream raw materials:

C₂₇H₃₃O₆P

C₂₇H₃₃O₆P

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