Technology Process of 7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
There total 8 articles about 7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: 91 percent / p-toluenesulfonic acid / toluene / 96 h / 130 °C
2: 99 percent / H2 / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature
3: 65 percent / pyridine / 48 h / 60 °C
4: 3 N aq. HCl / 48 h / 80 °C
5: aq. NaHCO3 / ethanol; tetrahydrofuran / 24 h / 45 °C
With
pyridine; hydrogenchloride; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1 M aq. NaOH / diethyl ether / 3 h
2: 91 percent / pyridine-SO3, Et3N / dimethylsulfoxide / 1 h / 0 °C
3: 91 percent / p-toluenesulfonic acid / toluene / 96 h / 130 °C
4: 99 percent / H2 / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature
5: 65 percent / pyridine / 48 h / 60 °C
6: 3 N aq. HCl / 48 h / 80 °C
7: aq. NaHCO3 / ethanol; tetrahydrofuran / 24 h / 45 °C
With
pyridine; hydrogenchloride; sodium hydroxide; hydrogen; sulfur trioxide pyridine complex; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dimethyl sulfoxide; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 91 percent / pyridine-SO3, Et3N / dimethylsulfoxide / 1 h / 0 °C
2: 91 percent / p-toluenesulfonic acid / toluene / 96 h / 130 °C
3: 99 percent / H2 / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature
4: 65 percent / pyridine / 48 h / 60 °C
5: 3 N aq. HCl / 48 h / 80 °C
6: aq. NaHCO3 / ethanol; tetrahydrofuran / 24 h / 45 °C
With
pyridine; hydrogenchloride; hydrogen; sulfur trioxide pyridine complex; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; ethyl acetate; toluene;
