4-(2,4-DICHLOROPHENYL)-4-PIPERIDINOL

Base Information

• Chemical Name: 4-(2,4-DICHLOROPHENYL)-4-PIPERIDINOL
• CAS No.: 945423-04-1
• Molecular Formula: C₁₁H₁₃Cl₂NO
• Molecular Weight: 246.136
• Mol file: 945423-04-1.mol

Synonyms:4-(2,4-dichlorophenyl)piperidin-4-ol

Chemical Property of 4-(2,4-DICHLOROPHENYL)-4-PIPERIDINOL

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

4-(2,4-Dichlorophenyl)-4-piperidinol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2,4-DICHLOROPHENYL)-4-PIPERIDINOL

There total 4 articles about 4-(2,4-DICHLOROPHENYL)-4-PIPERIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 4-(2,4-dichlorophenyl)-4-hydroxypiperidine-1-carboxylate (945423-03-0) → 4-(2,4-dichlorophenyl)piperidin-4-ol (945423-04-1)

Guidance literature:

tert-butyl 4-(2,4-dichlorophenyl)-4-hydroxypiperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(2,4-dichlorophenyl)piperidin-4-ol (945423-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/acs.jmedchem.9b00864

Reference yield:

1-bromo-2,4-dichlorobenzene (1193-72-2) → 4-(2,4-dichlorophenyl)piperidin-4-ol (945423-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/acs.jmedchem.9b00864

upstream raw materials:

tert-butyl 4-(2,4-dichlorophenyl)-4-hydroxypiperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

1-bromo-2,4-dichlorobenzene

Downstream raw materials:

2-benzyloxy-1-[4-(2,4-dichloro-phenyl)-4-hydroxy-piperidin-1-yl]-ethanone

Refernces

• 1、 -. "(4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE". Page/Page column 60. . Retrieved 2011/04/19.