ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

Base Information

Chemical Name:ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate
CAS No.:1309974-52-4
Molecular Formula:C₃₅H₃₉N₃O₈
Molecular Weight:629.71
Hs Code.:

Synonyms:ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

Suppliers and Price of ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

There total 6 articles about ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1309974-51-3
ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

: 1573-92-8
9-oxo-9H-fluorene-1-carboxylic acid

: 1309974-52-4
ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 100-39-0
benzyl bromide

: 1309974-52-4
ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / -20 °C

2.2: 0.5 h / Cooling with ice

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: dichloromethane / 48 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h

6.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With 4-methyl-morpholine; sodium hydride; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 4.1: Passerini Reaction;

Reference yield:

: 79069-15-1
N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol

: 1309974-52-4
ethyl 2-((3S)-4-(benzyloxy)-2-hydroxy-3-[((2S)-4-methyl-2-[(9-oxo-9H-1-fluorenyl)carbonyl]aminopentanoyl)amino]butanoylamino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: dichloromethane / 48 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h

4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 2: Passerini Reaction;