ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

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Chemical Name:ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate
CAS No.:1309974-51-3
Molecular Formula:C₂₁H₃₃N₃O₆
Molecular Weight:423.51
Hs Code.:

Synonyms:ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

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Chemical Property of ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

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Technology Process of ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

There total 5 articles about ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(2-ethoxy-2-oxoethyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoate

: 1309974-51-3
ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

Guidance literature:: (3S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(2-ethoxy-2-oxoethyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoate; With trifluoroacetic acid; In dichloromethane; for 0.5h;

With triethylamine; In dichloromethane;

Reference yield:

: 100-39-0
benzyl bromide

: 1309974-51-3
ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / -20 °C

2.2: 0.5 h / Cooling with ice

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: dichloromethane / 48 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h

With 4-methyl-morpholine; sodium hydride; Dess-Martin periodane; trifluoroacetic acid; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 4.1: Passerini Reaction;

Reference yield:

: 79069-15-1
N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol

: 1309974-51-3
ethyl 2-[(3S)-3-[(2S)-2-amino-4-methylpentanoyl]amino-4-(benzyloxy)-2-hydroxybutanoyl]aminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: dichloromethane / 48 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h

With Dess-Martin periodane; trifluoroacetic acid; In dichloromethane; 2: Passerini Reaction;