N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea

Base Information

• Chemical Name: N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea
• CAS No.: 110164-58-4
• Molecular Formula: C₂₀H₂₆N₄O₄S
• Molecular Weight: 418.517
• Mol file: 110164-58-4.mol

Synonyms:N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea

Chemical Property of N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea

There total 3 articles about N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(2-methoxyphenyl)piperazine hydrochloride (5464-78-8) → N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea (110164-58-4)

Guidance literature:

With sodium iodide; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;

Reference yield: 67.0%

1-(2-methoxyphenyl)piperazine hydrochloride (5464-78-8) + methyl 3-thiophene-2-carboxylate (110164-57-3) → N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea (110164-58-4)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; for 60h; Heating;

DOI:10.1021/jm00117a019

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → N-(2-carbomethoxythien-3-yl)-N'-[2-[4-[2-methoxyphenyl)piperazin-1-yl)ethyl]urea (110164-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / toluene / 3 h / Heating

2: 67 percent / NaHCO₃, NaI / tetrahydrofuran / 60 h / Heating

With sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; toluene;

DOI:10.1021/jm00117a019

upstream raw materials:

1-(2-methoxyphenyl)piperazine hydrochloride

methyl 3-thiophene-2-carboxylate

Methyl 3-aminothiophene-2-carboxylate

Downstream raw materials:

1-[4-(ethoxycarbonyl)butyl]-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]thieno[3,2-d]pyrimidine-2,4-dione

ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate

3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-1-(2,2-dimethyl-1-oxopropyl)thieno[3,2-d]pyrimidine-2,4-dione

1-acetyl-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]thieno[3,2-d]pyrimidine-2,4-dione