2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

Base Information

Chemical Name:2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol
CAS No.:136007-02-8
Molecular Formula:C₂₂H₁₈F₄O
Molecular Weight:374.378
Hs Code.:

Synonyms:2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

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Chemical Property of 2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

Chemical Property:

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Technology Process of 2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

There total 6 articles about 2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(4-Fluoro-phenyl)-hydroxy-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

: 136007-02-8
2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In acetic acid; at 25 ℃; for 1.5h; under 750.06 Torr;
DOI:10.1021/jm00114a004

Reference yield:

: 402-26-6
3-(trifluoromethyl)phenylmagnesium bromide

: 136007-02-8
2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran

2: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid;
DOI:10.1021/jm00114a004

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 136007-02-8
2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: tetrahydrofuran

4: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

With hydrogenchloride; sodium hydroxide; aluminium trichloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid;
DOI:10.1021/jm00114a004