methyl β-(2,3-dimethylbenzoyl)propanoate

Base Information

• Chemical Name: methyl β-(2,3-dimethylbenzoyl)propanoate
• CAS No.: 36440-59-2
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• Mol file: 36440-59-2.mol

Synonyms:methyl β-(2,3-dimethylbenzoyl)propanoate

Chemical Property of methyl β-(2,3-dimethylbenzoyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl β-(2,3-dimethylbenzoyl)propanoate

There total 5 articles about methyl β-(2,3-dimethylbenzoyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,3-dimethylbenzaldehyde (5779-93-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl β-(2,3-dimethylbenzoyl)propanoate (36440-59-2)

Guidance literature:

With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 18h; Reagent/catalyst; Temperature; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c8ob01287c

Reference yield: 76.0%

methyl β-(2,3-dimethyl-5-t-butylbenzoyl)propanoate (86306-28-7) → methyl β-(2,3-dimethylbenzoyl)propanoate (36440-59-2)

Guidance literature:

With aluminium trichloride; In benzene; 1.) 8 h, 65 deg C, 2.) overnight, room temperature;

Reference yield:

4-t-butyl-o-xylene (7397-06-0) → methyl β-(2,3-dimethylbenzoyl)propanoate (36440-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) AlCl₃, 2.) K₂CO₃ / 1.) nitrobenzene a) 3 h, ice-bath temperature raising to 30 deg C, b) 3 h, 30 - 40 deg C, 2.) acetone, 12 h, reflux

2: 76 percent / anhydrous AlCl₃ / benzene / 1.) 8 h, 65 deg C, 2.) overnight, room temperature

With aluminium trichloride; potassium carbonate; In benzene;

upstream raw materials:

2,3-dimethylbromobenzene

succinic acid monomethylester chloride

methyl β-(2,3-dimethyl-5-t-butylbenzoyl)propanoate

4-t-butyl-o-xylene

Downstream raw materials:

5,6-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one

4-(2,3-dimethylphenyl)butanoic acid

1,2,5-trimethylnaphthalene

methyl γ-(2,3-dimethylphenyl)butanoate